- Chocolate
and the Nervous System
-
Adam
Drewnowski at the University of Michigan researched whether chocolate
triggers the production of opioids. Opioids are chemicals, such as those
found in opium, that produce a feeling of well-being (euphoria). Drewnowski
found that eating chocolate causes the brain to produce natural opiates,
which dulI pain and increase a feeling of well-being. If the receptors
in the brain that signal the presence of opioids were blocked, chocolate
bingeing decreased. It was not shown, however, if this was caused by
the high fat or sugar content of chocolate candy.
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- Researchers at the NeuroScience
Institute in San Diego, Emmanuelle diTomaso (she's now at Harvard University)
and Daniele Piomelli (he's now at the University of California, Irvine)
looked into the chemical components of chocolate. They found three substances
in chocolate that "could act as cannabinoid mimics either directly
(by activating cannabinoid receptors) or indirectly (by increasing anandamide
levels)." What do all these big words mean? A little background
information may help make this more understandable.
- A receptor is a structure
on the surface of a cell that interacts with certain chemicals. Receptors
have different shapes, and thus interact with specific molecules. diTomaso
describes this interaction like this: "the active compound will
lock itself to the protein and that triggers a reaction inside the cell."
Cannabinoids are substances that act like cannabis, also known as marijuana.
The active chemical in marijuana is called tetrahydrocannabinol (THC),
and there are receptors in the brain that bind THC. When THC binds to
these receptors, the person feels "high." Anandamide is a
lipid that is normally found in the brain; it can bind to the same receptors
as THC and thus produce a similar effect to "being high."
-
- Does chocolate affect the
brain in the same way marijuana does? There are chemicals in chocolate
that act like THC, resulting in production of dopamine, a neurotransmitter.
However, there is no THC in chocolate, so you aren't breaking the law
by eating chocolate. One of the compounds in chocolate is anandamide,
which is already produced in your brain. If anandamide is already in
your brain, then why don't you feel happy all the time? Well, anandamide
is broken down quickly, so it isn't around long in your brain to make
you smile. But chocolate may extend the feelings of well being. Piomelli's
research indicates that there are two chemicals in chocolate which inhibit
the natural breakdown of anandamide. This may be a reason why we like
to eat chocolate! And dark chocolate contains more of these compounds
than milk chocolate.
-
- Eating a bar of chocolate
will not make you feel giddy or "high." This may be because
anandamide and the two compounds that enhance its effect are short-lived
and localized in the brain. THC activates many receptors throughout
the brain, so it has a much larger effect. Chocolate's effect is limited
because anandamide is not present all over the brain. Scientists doubt
if anandamide and other chemicals in chocolate have much effect because
they are present only in small amounts. Christian Felder at the National
Institute of Mental Health estimates that a 130-pound person would have
to eat 25 pounds of chocolate at one time to get any marijuana-like
effect. Also, since these compounds are eaten, it's difficult to determine
how much enters the bloodstream and actually reaches the brain.


- The Synapse
-
- There may also be other
explanations for the feelings caused by chocolate and these may have
nothing to do with cannabinoids, anandamide, or receptors. There are
many other components in chocolate that may play a role in its popularity.
Eating chocolate may be pleasurable because of a unique interaction
among a few of its components.
Chocolate
also contains phenylethylamine, a chemical related to amphetamines.
Like amphetamines, this chemical causes blood pressure and blood-sugar
levels to rise, resulting in a feeling of alertness and contentment.
Phenylethylamine has been called the "love-drug" because it
quickens your pulse, as if you are in love. Caffeine in chocolate may
also cause feelings of alertness and a pounding heart. Other stimulants
in chocolate include theobromine and methylxanthines. These caffeine-relatives
are weaker than caffeine-you'd have to eat more than 12 Hershey bars
to get as much caffeine as there is in one cup of coffee. All of these
stimulants increase the activity of neurotransmitters in the brain.
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