| Thomas Hunt Morgan |
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Francis Crick, James D. Watson, and Maurice Wilkins determined the molecular structure of DNA as a double helix or two intertwined spirals of phosphate and sugar molecules linked by pairs of organic bases. The sequences of the paired organic bases form the genetic code of an organism. The double helix structure is an eye-catching symbol that appears on many stamps, including the Czech Mendel stamp above, and examples from Liechtenstein and Israel below. Werner Arber (1929- ), Daniel Nathans (1928-), and Hamilton Smith (1931- ) received the 1978 Nobel prize in physiology or medicine for the "discovery of restriction enzymes and their application to problems of molecular genetics." They may be used to cut DNA into fragments. From these segments the sequence of genes in chromosomes may be studied, their structure may be analyzed, or the genes may be recombined in different order. Barbara McClintock's lifelong research interest was in the genetics of maize. She studied individual chromosomes and related them to the physical characteristics of the kernels on the cob, finding that changes in the color pattern of the kernels corresponded to the transposition of structural elements of the chromosomes, or "jumping genes." She made this discovery before the structure of DNA was known. |