was born at Hume, Illinois, on November 3, 1893. He was the son of Edward
Perez and his wife Ada, née Alley.
He was educated at the University of Illinois, where he took his A.B.
degree in 1914 and his M.S. degree in 1916. From there he went to Harvard
University, where he took his Ph.D. degree in 1920.
From 1915 until 1917 he was assistant in biochemistry at Harvard Medical
School and from 1917 until 1919 he did war service in the Sanitary Corps
of the United States Army. From 1919 until 1923 he was Instructor, Associate,
and Associate Professor at Washington University School of Medicine
and in 1923 he became Professor of Biochemistry at St. Louis University
School of Medicine. In 1924 he was appointed Director of the Department
Doisy has been concerned chiefly with biochemical studies of the sex
hormones and vitamins K1 and K2. At the St. Louis
School of Medicine he worked in collaboration with Edgar Allen on the
refinement of the vaginal cytology (or smear) technique for the big-assay
of the potency of oestrogenic hormones in ovariectomized rats.
In 1929-1930 he succeeded in isolating oestrone, a feat independently
accomplished at about the same time by Butenandt in Germany.
In 1936, in collaboration with MacCorquodale and Thayer, he recovered
oestradiol from the ovaries of swine and estimated its concentration
in the liquor folliculi.
In 1939 he succeeded in isolating vitamin K, which had been found, in
1935, by Almquist and Stokstad in alfalfa. Vitamin K was isolated in
an almost pure form as a yellow oil by Henrik Dam, in collaboration
with Paul Karrer.
In 1940 Doisy, in collaboration with Thayer, MacCorquodale, McKee, and
Binkley, studied the analogues of vitamin K and established the distinction
between vitamin K1 which they isolated from alfalfa, and
vitamin K2, isolated from fish meal, which has an action
similar to that of vitamin K1, but has a slightly different
Vitamin K was synthesized in 1939 by Louis Frederick Fieser and by Almquist
and Klose, and by Doisy and his collaborators.
For their work on vitamin K, Doisy and Dam were jointly awarded the
Nobel Prize in Physiology or Medicine for 1943.
In addition to the work just mentioned, Doisy has improved the methods
used for the isolation and identification of insulin and he has also
made important contributions to the knowledge of antibiotics and blood
buffer systems, and bile acid metabolism.
In 1939 Doisy published, in collaboration with Edgar Allen and C. H.
Danforth, a book entitled Sex and Internal Secretions.
Apart from several medals and awards, Doisy holds honorary degrees of
Yale, Washington, Chicago, Illinois, St. Louis, Central College; Gustavus
Adolphus College, and Paris Universities. In 1932 and 1935, he was a
member of the League of Nations Committee for the Standardization of
Sex Hormones. He was President of the American Society of Biological
Chemists in 1943-1945, of the Endocrine Society in 1949-1950, and of
the Society for Experimental Biology and Medicine in 1949-1951.
In 1955 his Department was renamed the Edward A. Doisy Department in
Doisy married Alice Ackert in 1918. They live at St. Louis, Mo, and
have four sons, Edward A. Jr., Robert, Philip, and Richard.
Nobel Lectures, Physiology or Medicine 1942-1962.
Doisy died in 1986.