| Themes > Science > Life Sciences > General Biology > Physiology > The Reproductive System > Human Development |
Fertilization, the fusion of the sperm and egg, usually occurs in the upper third of the oviduct. Thirty minutes after ejaculation, sperm are present in the oviduct, having traveled from the vagina through the uterus and into the oviduct. Sperm traverse this distance by the beating of their flagellum. Of the several hundred million sperm released in the ejaculation, only a few thousand reach the egg. Only one sperm will fertilize the egg. One sperm fuses with receptors on the surface of the secondary oocyte, triggering a series of chemical changes in the outer oocyte membrane that prevent any other sperm from entering the oocyte. The entry of the sperm initiates Meiosis II in the oocyte. Fusion of the egg and sperm nuclei forms the diploid zygote. Travels of a Young ZygoteCleavage of the zygote begins while it is still in the oviduct, producing a solid ball of cells (morula). The morula enters the uterus, continuing to divide and becomes a blastocyst. ![]() Stages in the journey of a fertilized egg from fertilization in the Fallopian tube to implantation in the uterus. The above image is from http://www.biosci.uga.edu/almanac/bio_103/notes/apr_11.html. ImplantationThe uterine lining becomes enlarged and prepared for implantation of the embryo in the trophoblast layer. Twelve days after fertilization, the trophoblast has formed a two-layered chorion. Human chorionic gonadotropin (hCG) is secreted by the chorion, and prolongs the life of the corpus luteum until the placenta begins to secrete estrogen and progesterone. Home pregnancy tests work by detecting elevated hCG levels in the woman's urine. Your Placenta or Mine?Maternal and embryonic structures interlock to form the placenta, the nourishing boundary between the mother's and embryo's systems. The umbilical cord extends from the placenta to the embryo, and transports food to and wastes from the embryo. ![]() Changes in the zygote from fertilization to implantation. The above image is from http://www.biosci.uga.edu/almanac/bio_103/notes/apr_15.html. StagesThe period of time from fertilization to birth (usually 9 months) is divided into trimesters, each about three months long. During pregnancy the zygote undergoes 40 to 44 rounds of mitosis, producing an infant containing trillions of specialized cells organized into tissues and organs. The First TrimesterThe three embryonic tissue layers form. Cellular differentiation begins to form organs during the third week. After one month the embryo is 5 mm long and composed mostly of paired somite segments. During the second month most of the major organ systems form, limb buds develop. The embryo becomes a fetus by the seventh week. Beginning the eighth week, the sexually neutral fetus activates gene pathways for sex determination, forming testes in XY fetuses and ovaries in XX fetuses. External genitalia develop. The Second TrimesterThe fetus increases in size during this trimester, and bony parts of the skeleton begin to form. Fetal movements can be felt by the mother. The Last TrimesterDuring this trimester the fetus increases in size. Circulatory and respiratory systems mature in preparation for air breathing. Fetal growth during this time uses large parts of its mother's protein and calcium intake. Maternal antibodies pass to the fetus during the last month, conferring temporary immunity. |
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